| Game Title | Country | Year | Publisher |
| Sapo Xule: O Mestre do Kung Fu | BR | 1995 | Tec Toy Industria de Brinquedos S.A. |
| Sapo Xule: S.O.S. Lagoa Poluida | BR | 1995 | Tec Toy Industria de Brinquedos S.A. |
| Scramble Spirits | US | 1989 | SEGA Enterprises Ltd. |
| SEGA World Tournament Golf | US | 19XX | SEGA Corporation |
| Shanghai | US | 1988 | SEGA of America, Inc. |
| Shining Force | US | 19XX | Unknown Publisher |
| Shinobi | US | 1988 | SEGA Enterprises Ltd., SEGA of America, Inc. |
| Shooting Gallery | US | 1987 | SEGA Enterprises Ltd., SEGA of America, Inc. |
| Slap Shot | US | 19XX | Unknown Publisher |
| Sonic and Knuckles | US | 19XX | Unknown Publisher |
| Sonic Blast | BR | 1997 | Tec Toy Industria de Brinquedos S.A. |
| Sonic the Hedgehog Chaos - GameGear | US | 1993 | SEGA Enterprises Ltd., Tec Toy Industria de Brinquedos S.A. |
| Sonic Drift - GameGear | US | 19XX | SEGA Enterprises Ltd., SEGA Corporation |
| Sonic the Hedgehog | US | 1991 | SEGA of America, Inc., Tec Toy Industria de Brinquedos S.A. |
| Sonic the Hedgehog 2 - GameGear | BR | 1992 | SEGA Enterprises Ltd., SEGA of America, Inc. |
| Sonic the Hedgehog 2 | US | 1992 | SEGA Enterprises Ltd., SEGA of America, Inc. |
| Sonic the Hedgehog Chaos | BR | 1993 | SEGA Enterprises Ltd., Tec Toy Industria de Brinquedos S.A. |
| Space Gun | JP | 1992 | Taito Corporation |
| Space Harrier | US | 1986 | SEGA of America, Inc. |
| Space Harrier 3-D | US | 1988 | SEGA Enterprises Ltd., SEGA of America, Inc. |
| SpellCaster | US | 1989 | SEGA Enterprises Ltd., SEGA of America, Inc. |
| Spy vs Spy | US | 1986 | SEGA Corporation |
| Star Wars | US | 1993 | U.S. Gold Ltd. |
| Street Fighter II': Special Champion Edition | BR | 1997 | Tec Toy Industria de Brinquedos S.A. |
| Streets of Rage | US | 1993 | SEGA Enterprises Ltd. |
| Streets of Rage 2 | BR | 1993 | SEGA Enterprises Ltd., Tec Toy Industria de Brinquedos S.A. |
| Strider | US | 1991 | SEGA Corporation |
| Strider 2 | US | 1992 | U.S. Gold Ltd. |
| Submarine Attack | BR | 1990 | SEGA Enterprises Ltd., Tec Toy Industria de Brinquedos S.A. |
| Sukeban Deka II | JP | 19XX | Unknown Publisher |
| Summer Games | US | 1988 | SEGA Corporation |
| Super Kick Off | US | 1991 | U.S. Gold Ltd. |
| Superman: The Man of Steel | US | 1993 | Virgin Games, Ltd. |
| Super Monaco GP | BR | 1990 | SEGA of America, Inc., Tec Toy Industria de Brinquedos S.A. |
| Super Racing | US |